As expected, CBD has been reported to interact with antiepileptic drugs, antidepressants, opioid painkillers and THC, but surprisingly, it interacts with several other common medications, for example, certain antiepileptic drugs, such as carbamazepine, oxcarbazepine, phenobarbital and phenytoin, can affect CBD metabolism and cause a decrease in CBD levels. Taking CBD with certain antimicrobials can cause increased levels of CBD in the blood, which can lead to negative side effects of CBD. Because the consumption of CBD can interfere with the function of CYP enzymes, mixing CBD and PPIs could lead to an increase in the side effects of PPIs. The side effects of CBD and antidepressants can also overlap, as CBD and antidepressants are associated with side effects on the central nervous system (CNS), such as sleepiness and sleep disturbances.
While CBD may be useful for some patients, more research is needed to evaluate the safety and effectiveness of CBD. As the potential uses of CBD continue to expand, more people are becoming interested in over-the-counter CBD products.